Daptomycin for Treating Deep Sternal Wound Infections After Cardiac Surgery
Author Information
Author(s): Popov Aron F, Schmitto Jan D, Jebran Ahmad F, Bireta Christian, Friedrich Martin, Rajaruthnam Direndra, Coskun Kasim O, Braeuer Anselm, Hinz Jose, Tirilomis Theodor, Schoendube Friedrich A
Primary Institution: University of Göttingen, Germany
Hypothesis
The study aims to quantify the application of daptomycin treatment for deep sternal wound infections (DSWI) due to gram-positive organisms post cardiac surgery.
Conclusion
Daptomycin treatment for DSWI due to gram-positive organisms is safe, effective, and promotes immediate improvement of local wound conditions.
Supporting Evidence
- The incidence of DSWI was 1.46%.
- 89% of patients used VAC therapy.
- All patients achieved successful wound healing.
- Mean daptomycin dose was 4.4 ± 0.9 mg/kg/d.
- Duration from daptomycin application to sternal closure was 18 ± 13.9 days.
- Significant reductions in infection parameters were observed after daptomycin application.
Takeaway
Doctors used a medicine called daptomycin to help patients with serious infections after heart surgery, and it worked really well for everyone.
Methodology
An observational analysis of 23 cases of post-sternotomy DSWI treated with daptomycin from February 2009 to September 2010.
Potential Biases
The study did not evaluate preoperative patients for staphylococcal carriers, which could affect results.
Limitations
The study is observational with a small sample size and results may not be generalizable to other settings.
Participant Demographics
{"age":"71.04 ± 10.77 years","gender":{"male":17,"female":6},"comorbidities":{"hypertension":20,"diabetes":7,"obesity":4}}
Statistical Information
P-Value
p = 0.03 for fibrinogen, p = 0.001 for WBC, p = 0.0001 for CRP
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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