Effects of Plant Polyphenols on Fat Cell Secretions
Author Information
Author(s): Christos S. Derdemezis, Dimitrios N. Kiortsis, Vasilis Tsimihodimos, Maria P. Petraki, Patra Vezyraki, Moses S. Elisaf, Alexandros D. Tselepis
Primary Institution: University of Ioannina
Hypothesis
The study investigates the effects of quercetin, EGCG, and resveratrol on adipokine secretion from human adipocytes.
Conclusion
Quercetin and resveratrol significantly decreased visfatin secretion from SGBS adipocytes.
Supporting Evidence
- Quercetin reduced visfatin secretion by 16% and 24% at 10 μM after 24 and 48 hours.
- Resveratrol at 25 μM decreased visfatin by 28% and 38% at 24 and 48 hours.
- EGCG did not affect visfatin secretion.
Takeaway
This study looked at how certain plant compounds affect the substances that fat cells release, finding that two of them can lower a specific fat-related protein.
Methodology
Human SGBS adipocytes were treated with quercetin, EGCG, and resveratrol for 24 and 48 hours, and adipokine levels were measured in the supernatant.
Limitations
The study only tested three polyphenols and did not explore their effects on other adipokines.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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