Skeletal Muscle Mitochondrial Function and Longitudinal Changes in Brain Structure
2024
Mitochondrial Function and Brain Changes
Sample size: 649
publication
Evidence: moderate
Author Information
Author(s): Tian Teresa, Greig Erin, Davatzikos Christos, Landman Bennett, Resnick Susan, Ferrucci Luigi
Primary Institution: National Institute on Aging
Hypothesis
Is mitochondrial dysfunction associated with accelerated loss in brain volumes and microstructural integrity?
Conclusion
Higher mitochondrial function is linked to less brain aging and atrophy.
Supporting Evidence
- Higher kPCr was associated with less ventricular enlargement.
- Higher kPCr correlated with less worsening in brain aging scores.
- Less regional atrophy was observed with higher kPCr.
- Higher kPCr linked to less microstructural integrity loss in white matter.
Takeaway
If your muscles work better, your brain might stay healthier as you get older.
Methodology
Longitudinal study using MR spectroscopy and brain MRI over up to 12 years.
Participant Demographics
Participants from the Baltimore Longitudinal Study of Aging.
Digital Object Identifier (DOI)
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