Tmem26 and Its Role in Mouse Development
Author Information
Author(s): Town Liam, McGlinn Edwina, Davidson Tara-Lynne, Browne Catherine M., Chawengsaksophak Kallayanee, Koopman Peter, Richman Joy M., Wicking Carol
Primary Institution: Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
Hypothesis
Is Tmem26 required for embryonic survival and development?
Conclusion
The study found that Tmem26 is dynamically expressed during palate and limb development but is not essential for embryonic survival.
Supporting Evidence
- Tmem26 expression is restricted in the developing facial prominences and palatal structures.
- Ubiquitous inactivation of Tmem26 led to no overt phenotype in embryos or adult mice.
- Tmem26 is not required for embryonic survival.
Takeaway
Tmem26 is a gene that helps with the development of certain body parts in mice, but mice can grow up just fine without it.
Methodology
The researchers used targeted gene inactivation in mice to study the role of Tmem26 during development.
Limitations
The study did not explore potential subtle phenotypes that may arise from the absence of Tmem26.
Digital Object Identifier (DOI)
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