Viral Genetic Factors in HIV Virulence
Author Information
Author(s): Viktor Müller, Christophe Fraser, Joshua T. Herbeck
Primary Institution: Eötvös Loránd University
Hypothesis
The role of viral genetic factors in the variation of HIV virulence has been poorly characterized.
Conclusion
Recent studies demonstrate a robust effect of viral genotype on HIV virulence.
Supporting Evidence
- HIV infections show great variation in the rate of progression to disease.
- Recent studies have filled the gap in understanding the role of viral genetic factors in HIV virulence.
- The heritability of virus load has been shown to correlate within transmission pairs.
Takeaway
Some viruses make people sick faster than others, and scientists are learning that the genes of the virus can affect how quickly someone gets sick from HIV.
Methodology
The commentary discusses findings from multiple studies that investigated the correlation of virus loads within transmission pairs.
Potential Biases
Potential confounding factors such as shared environmental influences within transmission pairs could bias heritability estimates.
Limitations
The studies involved relatively small samples and varied methodologies, which may affect the estimates of heritability.
Participant Demographics
The studies included patient cohorts characterized by European or African ancestry and various modes of exposure.
Digital Object Identifier (DOI)
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