Trumped Treatment?: BPA Blocks Effects of Breast Cancer Chemotherapy Drugs
2009
BPA Blocks Effects of Breast Cancer Chemotherapy Drugs
publication
Author Information
Author(s): Barrett Julia R.
Primary Institution: National Institute of Environmental Health Sciences
Hypothesis
How does BPA influence the efficacy of chemotherapy drugs in breast cancer treatment?
Conclusion
BPA reduces the effectiveness of chemotherapy drugs in breast cancer cells by preventing programmed cell death.
Supporting Evidence
- BPA at concentrations found in the general population reduces the efficacy of chemotherapy drugs.
- BPA increases cell viability in certain breast cancer cells.
- BPA's effects are not mediated by classical estrogen receptors.
Takeaway
BPA, a chemical found in many products, can make breast cancer treatments less effective by stopping cancer cells from dying.
Methodology
The study used cell cultures of breast cancer cells treated with BPA and chemotherapy drugs to assess cell survival and protein expression.
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