INSIG2 Gene and Fat in Women and Men
Author Information
Author(s): Funda E Orkunoglu-Suer, Heather Gordish-Dressman, Priscilla M Clarkson, Paul D Thompson, Theodore J Angelopoulos, Paul M Gordon, Niall M Moyna, Linda S Pescatello, Paul S Visich, Robert F Zoeller, Brennan Harmon, Richard L Seip, Eric P Hoffman, Joseph M Devaney
Primary Institution: Children's National Medical Center
Hypothesis
The study investigates the relationship between the INSIG2 SNP and subcutaneous fat volumes in a young adult population.
Conclusion
The INSIG2 rs7566605 polymorphism is linked to increased subcutaneous fat in women and a poor response to resistance training in men.
Supporting Evidence
- Women with the C allele had higher baseline subcutaneous fat.
- Men with the C allele gained more subcutaneous fat with resistance training.
- The study used MRI to measure fat volumes, providing a sensitive measure of adiposity.
Takeaway
This study found that a specific gene variant can affect how much fat women have and how men respond to exercise.
Methodology
The study genotyped the INSIG2 SNP in a controlled resistance-training program and measured subcutaneous fat using MRI.
Limitations
The study did not control for diet and did not analyze visceral fat.
Participant Demographics
752 healthy Caucasian volunteers aged 18-40 years, including 451 women and 301 men.
Statistical Information
P-Value
0.0011 for women; 0.035 for men
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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