West Nile Virus: Immunity and Pathogenesis
Author Information
Author(s): Stephanie M. Lim, Penelope Koraka, Albert D.M.E. Osterhaus, Byron E.E. Martina
Primary Institution: Erasmus MC
Hypothesis
The involvement of the CNS is associated with a weak immune response allowing robust WNV replication in the periphery and spread of the virus to the CNS.
Conclusion
The immune system plays a critical role in controlling West Nile virus infection, but its dysfunction can lead to severe disease.
Supporting Evidence
- WNV is endemic in parts of Africa, Europe, the Middle East, and Asia.
- Symptoms of WNV infection can include fever, headache, and in severe cases, encephalitis.
- Immunocompromised individuals are at increased risk for severe disease.
- An intact immune system is essential for controlling WNV infection.
Takeaway
West Nile virus can make people very sick, especially older folks or those with weak immune systems, and understanding how our body fights it can help us find better treatments.
Methodology
This review discusses immune responses and mechanisms of pathogenesis related to West Nile virus infection.
Limitations
The exact immunological basis for increased susceptibility in the elderly remains unclear.
Participant Demographics
The review highlights that the elderly and immunocompromised individuals are at higher risk for severe disease.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website