Vaccination with Endothelial Cells to Fight Melanoma
Author Information
Author(s): Yoshiura Kenta, Nishishita Toshihide, Nakaoka Takashi, Yamashita Naohide, Yamashita Naomi
Primary Institution: Research Institute of Pharmaceutical Sciences, Musashino University
Hypothesis
Can vaccination with a syngeneic endothelial cell line inhibit melanoma growth and metastasis?
Conclusion
Vaccination with an autologous endothelial cell line may be effective against melanoma.
Supporting Evidence
- Vaccination with Tpit/E cells inhibited subcutaneous tumor growth compared to control.
- Survival period was elongated in the Tpit/E vaccination group.
- Specific immune response to the syngeneic endothelial cells was elicited.
Takeaway
The study shows that giving mice a vaccine made from their own blood vessel cells can help stop skin cancer from growing and spreading.
Methodology
C57BL/6J mice were vaccinated with a syngeneic endothelial cell line and then challenged with melanoma cells to monitor tumor growth and metastasis.
Limitations
The study was conducted in mice, and the applicability to humans needs further investigation.
Participant Demographics
C57BL/6J mice, aged six to eight weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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