Plasma Volume Expansion from Glucose Tolerance Test
Author Information
Author(s): Robert G. Hahn, Thomas Nyström
Primary Institution: Linköping University
Hypothesis
To quantify the degree of plasma volume expansion that occurs during an intravenous glucose tolerance test (IVGTT).
Conclusion
The IVGTT caused an acute plasma volume expansion that peaked at 10% despite only a small amount of fluid being administered.
Supporting Evidence
- The IVGTT caused a virtually instant plasma volume expansion of 10%.
- Most of the volume expansion was allocated from the intracellular fluid space by osmosis.
- Simulations indicated that plasma volume expansion can be reduced by adjusting the glucose dose and injection time.
Takeaway
When you get a glucose test, your blood volume can expand quickly by about 10% because of the sugar solution they give you.
Methodology
Twenty healthy volunteers underwent IVGTTs with blood samples collected over 75 minutes to measure plasma glucose and hemoglobin concentrations.
Potential Biases
The study was conducted on healthy volunteers, which may not represent the response in diabetic or elderly patients.
Limitations
No invasive hemodynamic monitoring was performed, which could be important in patients with reduced cardiovascular reserves.
Participant Demographics
20 healthy volunteers, 8 females and 12 males, aged 18 to 51 years (mean age 28).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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