Study of a Genetic Variation in the IDO1 Gene and Its Impact on Tryptophan Levels
Author Information
Author(s): Soichot Marion, Hennart Benjamin, Al Saabi Alaa, Leloire Audrey, Froguel Philippe, Levy-Marchal Claire, Poulain-Godefroy Odile, Allorge Delphine
Primary Institution: Université Lille-Nord de France
Hypothesis
The study investigates the association between a VNTR polymorphism in the IDO1 promoter and serum tryptophan concentrations.
Conclusion
The VNTR polymorphism in the IDO1 promoter is associated with lower serum tryptophan concentrations in females, suggesting a role in IDO1 expression variability.
Supporting Evidence
- A VNTR polymorphism was identified in the IDO1 promoter that correlates with serum tryptophan concentration.
- The study involved 94 healthy Caucasian subjects to assess the impact of the VNTR on IDO activity.
- Significant differences in serum tryptophan levels were observed between males and females.
- Functional analyses revealed novel cis-acting elements in the IDO1 promoter.
Takeaway
This study found a genetic change in a gene that helps control tryptophan levels, which is important for mood and immune function, especially in women.
Methodology
PCR-sequencing strategy was used to identify a VNTR polymorphism in the IDO1 promoter from DNA samples of healthy Caucasians.
Limitations
The study primarily focused on a specific population (Caucasians), which may limit the generalizability of the findings.
Participant Demographics
Healthy Caucasian individuals, with 47 males and 47 females in the study.
Statistical Information
P-Value
0.0006
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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