Low Adiponectin Levels and Coronary Plaque
Author Information
Author(s): Uli C. Broedl, Corinna Lebherz, Michael Lehrke, Renee Stark, Martin Greif, Alexander Becker, Franz von Ziegler, Janine Tittus, Maximilian Reiser, Christoph Becker, Burkhard Göke, Klaus G. Parhofer, Alexander W. Leber
Primary Institution: University of Munich, Munich, Germany
Hypothesis
Are low serum adiponectin levels associated with coronary atherosclerotic plaque burden and morphology?
Conclusion
Low adiponectin levels predict mixed and non-calcified coronary atherosclerotic plaque burden.
Supporting Evidence
- Adiponectin levels were inversely correlated with total coronary plaque burden.
- Adiponectin levels accounted for approximately 20% of the variability in mixed and non-calcified plaque burden.
- No correlation was seen with calcified plaques.
Takeaway
If you have low levels of a substance called adiponectin, it might mean you have more dangerous types of heart plaque that can lead to heart problems.
Methodology
Serum adiponectin levels were measured in patients who underwent CT-angiography to assess coronary artery plaques.
Potential Biases
The study may not be applicable to diabetic patients as they were underrepresented.
Limitations
The study does not establish a causal relationship between adiponectin and coronary plaque morphology.
Participant Demographics
303 patients with stable chest pain, median age 63, 202 males and 101 females.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95%CI: −0.052 to −0.020
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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