Latanoprost vs Other Prostaglandin Analogs for Eye Pressure
Author Information
Author(s): Honrubia F, García-Sánchez J, Polo V, de la Casa J M Martínez, Soto J
Primary Institution: Hospital Miguel Servet, Zaragoza, Spain
Hypothesis
Does latanoprost cause less conjunctival hyperaemia compared to travoprost and bimatoprost in patients with ocular hypertension or glaucoma?
Conclusion
Latanoprost is associated with a lower incidence of conjunctival hyperaemia compared to travoprost and bimatoprost in treating patients with ocular hypertension or glaucoma.
Supporting Evidence
- Latanoprost produced lower occurrence of conjunctival hyperaemia than travoprost.
- Latanoprost also caused less conjunctival hyperaemia compared to bimatoprost.
- The study included 2222 patients across 13 randomized clinical trials.
Takeaway
This study found that using latanoprost for eye pressure is better because it causes less redness in the eyes than two other similar medicines.
Methodology
A meta-analysis of 13 randomized clinical trials comparing latanoprost with travoprost and bimatoprost.
Potential Biases
Potential publication bias due to the exclusion of unpublished studies.
Limitations
The study may have location bias and included only published studies in English, which could affect the generalizability of the results.
Participant Demographics
Patients aged 58 to 73 years, with 41.4% men and 61.4% suffering from open-angle glaucoma.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI 0.39 to 0.67
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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