Canalization of Gene Expression in Drosophila
Author Information
Author(s): Manu, Surkova Svetlana, Spirov Alexander V., Gursky Vitaly V., Janssens Hilde, Kim Ah-Ram, Radulescu Ovidiu, Vanario-Alonso Carlos E., Sharp David H., Samsonova Maria, Reinitz John
Primary Institution: Stony Brook University
Hypothesis
Canalization is a manifestation of the stability of developmental trajectories in Drosophila embryos.
Conclusion
The study demonstrates that the reduction in variability of gap gene expression and shifts in gene domains are driven by attractors in the dynamical system of gap genes.
Supporting Evidence
- The study confirms that the variation in gap gene expression patterns decreases over time.
- It identifies two distinct dynamical regions in the early embryo that influence gene expression stability.
- The results provide a mathematical characterization of the canalization process in Drosophila.
Takeaway
This study shows that fruit fly embryos can stabilize their development despite changes, thanks to special patterns in how their genes work together.
Methodology
The study used a mathematical model to analyze the dynamics of gene expression in Drosophila embryos, focusing on the gap gene network.
Limitations
The model's behavior must be robust to perturbations, and the analysis is limited to specific developmental stages.
Digital Object Identifier (DOI)
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