Salmonella takes control: effector-driven manipulation of the host
2009
How Salmonella Manipulates Host Cells
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Emma J. McGhie, Lyndsey C. Brawn, Peter J. Hume, Daniel Humphreys, Vassilis Koronakis
Primary Institution: University of Cambridge, Department of Pathology
Hypothesis
How do Salmonella effector proteins manipulate host cell functions during infection?
Conclusion
Salmonella uses specialized effector proteins to manipulate host cell processes, aiding in its invasion and replication.
Supporting Evidence
- Salmonella can invade non-phagocytic epithelial cells by manipulating the host's actin cytoskeleton.
- Over thirty effector proteins are involved in subverting host cell functions.
- Effector proteins can induce inflammation and alter immune responses.
Takeaway
Salmonella bacteria have special tools that help them sneak into our cells and make themselves at home, which can make us sick.
Methodology
This review summarizes the actions of Salmonella effector proteins on host cell targets during infection.
Limitations
The review does not provide experimental data but rather summarizes existing knowledge.
Digital Object Identifier (DOI)
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