Host Genetics of Infectious Diseases: Old and New Approaches Converge
1998
Host Genetics of Infectious Diseases: Old and New Approaches Converge
Commentary
Evidence: moderate
Author Information
Author(s): Adrian V.S. Hill
Primary Institution: University of Oxford
Conclusion
The study discusses the convergence of various genetic approaches to understanding susceptibility to infectious diseases.
Supporting Evidence
- Candidate gene studies have linked specific genes to malaria resistance.
- Mouse genetics has identified loci that influence susceptibility to infections.
- Complex segregation analysis suggests a major gene may influence susceptibility to diseases like leprosy and TB.
- Genomewide scans are being used to identify major susceptibility genes.
Takeaway
Scientists are trying to figure out why some people get sick from infections while others don't, and they are using different methods to find the important genes.
Methodology
The commentary reviews various genetic approaches including candidate gene studies, mouse genetics, complex segregation analysis, and genomewide analysis.
Potential Biases
There may be publication bias in reporting major genes.
Limitations
The commentary notes that many studies have small sample sizes and may miss important genes.
Statistical Information
Statistical Significance
p<0.05
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