Anti-H. pylori Effects of Byrsonima crassa Extracts
Author Information
Author(s): Cibele Bonacorsi, Maria Stella G Raddi, Iracilda Z Carlos, Miriam Sannomiya, Wagner Vilegas
Primary Institution: Universidade Estadual Paulista (UNESP)
Hypothesis
Can extracts from Byrsonima crassa inhibit Helicobacter pylori and stimulate immune response?
Conclusion
Byrsonima crassa extracts show potential anti-H. pylori activity but should be used cautiously due to their immunostimulatory effects.
Supporting Evidence
- Both methanolic and chloroformic extracts inhibited H. pylori growth with a MIC of 1024 μg/ml.
- The methanolic extract induced the production of hydrogen peroxide and nitric oxide.
- The chloroformic extract only induced nitric oxide production.
Takeaway
This study found that a plant called Byrsonima crassa can help fight a stomach germ called H. pylori, but it might also cause some problems if not used carefully.
Methodology
The study used broth microdilution to determine the minimal inhibitory concentration (MIC) and measured reactive oxygen/nitrogen intermediates in murine macrophages.
Limitations
The study does not provide data on the long-term effects or safety of using B. crassa extracts in humans.
Participant Demographics
Swiss mice (6–8 weeks old, 18 to 25 g) were used for the experiments.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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