Leptin and Fatty Acids Effects on Leukemic Cells
Author Information
Author(s): Beaulieu Aurore, Poncin Géraldine, Belaid-Choucair Zakia, Humblet Chantal, Bogdanovic Gordana, Lognay Georges, Boniver Jacques, Defresne Marie-Paule
Primary Institution: University of Liege
Hypothesis
Adipocytes and lipids could be involved in the progression of chronic myeloid leukemia (CML).
Conclusion
Adipocytes induced a decrease in CML proliferation and an increase in lipid accumulation in leukemic cells.
Supporting Evidence
- Adipocytes induced a decrease in CML proliferation.
- Lipid accumulation was observed in leukemic cells when co-cultured with adipocytes.
- α-Linolenic acid decreased the proliferation and survival of CML cell lines.
Takeaway
This study found that fat cells can affect leukemia cells by changing how they grow and survive, especially when certain fats are present.
Methodology
Adipocytes were co-cultured with BCR-ABL positive cell lines and treated with various fatty acids to assess their effects on proliferation and survival.
Limitations
The study primarily focused on in vitro conditions, which may not fully replicate in vivo environments.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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