Human 5-HT4 and 5-HT7 Receptor Splice Variants: Are they Important?
2007
Importance of 5-HT4 and 5-HT7 Receptor Splice Variants
publication
Evidence: moderate
Author Information
Author(s): Ian M Coupar, Paul V Desmond, Helen R Irving
Primary Institution: Monash University
Hypothesis
Are 5-HT4 and 5-HT7 receptor splice variants important for drug targeting?
Conclusion
The study highlights the potential of 5-HT4 and 5-HT7 receptor splice variants as future drug targets due to their tissue-specific expression and functional relevance.
Supporting Evidence
- 5-HT4 and 5-HT7 receptors have multiple splice variants that are tissue-specific.
- Splice variants can influence drug efficacy and safety.
- Understanding splice variants may lead to better-targeted therapies.
Takeaway
This study looks at special versions of serotonin receptors that might help in making better medicines for different diseases.
Methodology
The review discusses the discoveries, nomenclature, structures, and functional relevance of 5-HT4 and 5-HT7 receptor splice variants.
Limitations
The study primarily relies on existing literature and may not include new experimental data.
Digital Object Identifier (DOI)
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