Raspberry Ketone's Effect on Skin Whitening
Author Information
Author(s): Chia-Hsiang Victor Lin, Ding Hsiou-Yu, Kuo Shiou-Yi, Chin Ling-Wei, Wu Jiumn-Yih, Chang Te-Sheng
Primary Institution: E-Da Hospital, Kaohsiung, Taiwan
Hypothesis
Does raspberry ketone inhibit melanogenesis in vitro and in vivo?
Conclusion
Raspberry ketone significantly inhibits melanogenesis in both cultured melanoma cells and animal models, suggesting its potential use in cosmetics.
Supporting Evidence
- Raspberry ketone reduced melanin content in B16 melanoma cells.
- RK treatment led to significant skin whitening in mice within one week.
- RK did not show cytotoxicity in B16 cells.
- RK inhibited tyrosinase activity in both B16 cells and zebrafish.
- RK's skin-whitening effect was comparable to that of hydroquinone.
Takeaway
Raspberry ketone can help make skin lighter by stopping the production of a pigment called melanin.
Methodology
The study evaluated the effects of raspberry ketone on melanogenesis using in vitro B16 melanoma cells and in vivo zebrafish and mice models.
Limitations
The study did not confirm the reduction of tyrosinase protein in zebrafish due to lack of specific antibodies.
Participant Demographics
Mice used were C57BL/6J, weighing around 20 to 25 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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