Heme Oxygenase-1 Polymorphisms and Lung Function
Author Information
Author(s): Tanaka Goh, Aminuddin Farzian, Akhabir Loubna, He Jian-Qing, Shumansky Karey, Connett John E, Anthonisen Nicholas R, Abboud Raja T, Paré Peter D, Sandford Andrew J
Primary Institution: UBC James Hogg Research Center, Providence Heart + Lung Institute, St. Paul's Hospital, Vancouver, B.C., Canada
Hypothesis
Are HMOX1 polymorphisms associated with lung function in COPD patients?
Conclusion
The study found no association of the five HMOX1 tag SNPs with lung function decline.
Supporting Evidence
- The study genotyped five SNPs in the HMOX1 gene.
- A nominal association was found between rs2071749 and lung function decline.
- No significant effects on gene expression were found in reporter gene assays.
Takeaway
The researchers looked at gene variations to see if they affected lung health in smokers, but they didn't find any links.
Methodology
Genotyping of five SNPs in the HMOX1 gene among smokers with varying lung function decline.
Limitations
The association did not survive correction for multiple comparisons.
Participant Demographics
Caucasian smokers with mild to moderate airway obstruction.
Statistical Information
P-Value
0.015
Statistical Significance
p=0.015
Digital Object Identifier (DOI)
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