Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model
2007
The Role of c-Jun in Breast Cancer Metastasis
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Zhang Yan, Pu Xiaoyun, Shi Ming, Chen Liyong, Song Yuhua, Qian Lu, Yuan Guogang, Zhang Hao, Yu Ming, Hu Meiru, Shen Beifen, Guo Ning
Primary Institution: Institute of Basic Medical Sciences, Beijing, PR China
Hypothesis
The study investigates the role of c-Jun overexpression in the metastasis of breast cancer cells.
Conclusion
Overexpression of c-Jun contributes to a more invasive phenotype in MCF-7 cells and is involved in liver metastasis.
Supporting Evidence
- Ectopic overexpression of c-Jun promoted the growth of MCF-7 cells.
- MCF-7/c-Jun cells showed increased motility and invasiveness.
- Three out of six mice developed visible liver metastases after injection of MCF-7/c-Jun cells.
Takeaway
This study shows that a protein called c-Jun makes breast cancer cells more likely to spread to the liver.
Methodology
The study involved in vitro experiments with MCF-7 cells and in vivo experiments using nude mice to assess tumor growth and metastasis.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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