Kidney Health and Cognitive-Physical Function in Older Adults
Author Information
Author(s): Shrestha Aman, Shardell Michelle, Chen Chixiang, Seliger Stephen L, Ginsberg Charles, Miller Lindsay, Tian Teresa, Simonsick Eleanor
Primary Institution: University of Maryland School of Medicine
Hypothesis
The study investigates the association between kidney function markers and dual trajectories of cognitive and physical function in older adults.
Conclusion
The findings suggest that kidney health may play a role in cognitive and physical performance among initially healthy older adults.
Supporting Evidence
- Higher estimated glomerular filtration rate is associated with lower odds of poor cognitive-physical performance.
- Log-transformed urine albumin-to-creatinine ratio is linked to greater odds of declining cognitive-physical function.
- FGF23 is significantly associated with cognitive-physical trajectory.
Takeaway
This study looks at how kidney health affects thinking and movement in older people, showing that better kidney function is linked to better performance.
Methodology
Grouped-based trajectory analysis and multinomial regression models were used to assess associations between kidney function markers and cognitive-physical trajectories.
Participant Demographics
Initially healthy older adults from the Health, Aging and Body Composition Study.
Statistical Information
P-Value
0.044
Confidence Interval
95%CI: 0.97–0.99; 95%CI: 1.05–1.35; 95%CI: 1.17–1.55; 95%CI: 1.00–2.28
Statistical Significance
p=0.044
Digital Object Identifier (DOI)
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