Study of Mammalian Gene Batteries and Their Evolution
Author Information
Author(s): Ettwiller Laurence, Budd Aidan, Spitz François, Wittbrodt Joachim
Primary Institution: EMBL-Heidelberg
Hypothesis
How do cis-regulatory changes impact gene regulatory networks across eukaryotes?
Conclusion
The study reveals that gene batteries exhibit both stable ancestral cores and dynamic regulatory sequences, which are crucial for evolutionary innovation.
Supporting Evidence
- Gene batteries show variable conservation within vertebrates.
- The POU5F1 and SOX2 batteries are conserved in mammals but not in rodents.
- Turnover of transcription factor binding sites is common in regulatory sequences.
Takeaway
This study looks at how genes are controlled in different animals and finds that some parts stay the same over time while others change a lot, helping species to adapt.
Methodology
The study analyzed 16 publicly available ChIP datasets across 25 eukaryotic species to assess gene battery conservation and regulatory dynamics.
Limitations
The study primarily focuses on promoter regions and may not capture all regulatory changes.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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