Effects of Sirolimus Delivery Film in Rabbit Glaucoma Surgery
Author Information
Author(s): Yan Zhi-chao, Bai Yu-jing, Tian Zhen, Hu Hai-yan, You Xiu-hua, Lin Jian-xian, Liu Shao-rui, Zhuo Ye-hong, Luo Rong-jiang
Primary Institution: The First Affiliated Hospital, Sun Yat-Sen University
Hypothesis
The study investigates the efficacy, safety, and mechanisms of Sirolimus sustained delivery film on prevention of scar formation in a rabbit model of glaucoma filtration surgery.
Conclusion
Sirolimus drug sustained delivery film can inhibit inflammatory cell activity, impede fibroblast proliferation activity, and induce fibroblast apoptosis in the filtration surgery sites in rabbits.
Supporting Evidence
- Sirolimus sustained delivery film significantly prolonged bleb survival compared to no drug treatment groups.
- Group A had the longest bleb survival time compared to other groups.
- Histologic examination showed reduced fibroblast scar tissue formation in Sirolimus treated eyes.
Takeaway
This study tested a special film that slowly releases a medicine called Sirolimus to help prevent scarring after eye surgery in rabbits, and it worked well.
Methodology
Sixty-four rabbits were divided into four groups, each receiving different treatments, and evaluated for intraocular pressure, bleb morphology, and histological changes over 28 days.
Limitations
The study is limited to a rabbit model, which may not fully represent human responses.
Participant Demographics
New Zealand white rabbits, aged 10-12 weeks, weighing 2-2.8 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.001
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