Transcriptional Networks in Epithelial-Mesenchymal Transition
2011
Transcriptional Control of Epithelial-Mesenchymal Transition
publication
Evidence: moderate
Author Information
Author(s): Venkov Christo, Plieth David, Ni Terri, Karmaker Amitava, Bian Aihua, George Alfred L. Jr, Neilson Eric G.
Primary Institution: Vanderbilt University School of Medicine
Hypothesis
The study investigates the transcriptional networks involved in the epithelial-mesenchymal transition (EMT) process.
Conclusion
The study identifies new transcriptional interactions that modulate the stability of cellular plasticity during EMT.
Supporting Evidence
- The study identifies four key transcription factors that are crucial for the initiation and propagation of EMT.
- Blocking specific cis-regulatory elements leads to apoptosis in cells undergoing EMT.
- Gene expression patterns change significantly during the transition from epithelial to fibroblast-like cells.
Takeaway
When cells change from one type to another, they go through a process called EMT, and this study looks at how certain genes help control that change.
Methodology
The study used DNA microarray analysis to detect gene expression patterns during EMT at three time points.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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