Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease
Author Information
Author(s): Mulugeta Ezra, Londos Elisabet, Hansson Oskar, Ballard Clive, Skogseth Ragnhild, Minthon Lennart, Blennow Kaj, Zetterberg Henrik, Aarsland Dag
Primary Institution: Centre for Age-Related Medicine, Stavanger University Hospital
Hypothesis
The study aims to examine the CSF levels of sAPPα and sAPPβ in patients with Alzheimer's disease, Lewy body dementia, Parkinson's disease dementia, and normal controls.
Conclusion
The CSF levels of sAPPα and sAPPβ did not differ between Alzheimer's disease, Lewy body dementia, and normal controls, but there were disease-specific differences in their associations with Aβ and Tau species.
Supporting Evidence
- Significant correlations were observed between sAPPα and sAPPβ levels.
- MMSE scores correlated significantly with both sAPPα and sAPPβ in the total group.
- In the LBD group, significant correlations were found between sAPPα and sAPPβ with all Aβ species and T-Tau.
- In the AD group, a significant association was observed between sAPPβ and Aβ40.
Takeaway
The study looked at brain fluid levels of certain proteins in people with different types of dementia and found that these levels were similar across groups, but how they relate to other brain markers varied.
Methodology
Cerebrospinal fluid levels of sAPPα and sAPPβ were measured in 107 patients using commercial kits, with significant correlations analyzed between these levels and clinical scores.
Potential Biases
Patients were recruited from two different centers, which may introduce variability despite harmonized diagnostic procedures.
Limitations
The study had a relatively small number of patients, which may limit statistical power, and controls were not assessed with standard neuropsychological tests.
Participant Demographics
Participants included patients with Alzheimer's disease, Lewy body dementia, Parkinson's disease dementia, and normal controls, with a mean age around 74 years.
Statistical Information
P-Value
0.68 for sAPPα, 0.59 for sAPPβ
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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