Cognitive Reserve in Aging and Preclinical Alzheimer’s Disease
2024
Cognitive Reserve in Aging and Preclinical Alzheimer’s Disease
Sample size: 300
publication
Evidence: moderate
Author Information
Author(s): Soldan Anja, Pettigrew Corinne, Albert Marilyn
Primary Institution: Johns Hopkins University
Hypothesis
Higher levels of cognitive reserve are associated with better cognitive performance and delayed onset of Mild Cognitive Impairment.
Conclusion
The study found that cognitive reserve is linked to better cognitive outcomes, even in the presence of Alzheimer’s disease pathology.
Supporting Evidence
- Higher cognitive reserve is associated with better cognitive performance.
- Cognitive reserve delays the onset of Mild Cognitive Impairment.
- Cognitive reserve measures are linked to white matter integrity.
- Modifiable lifestyle factors can enhance cognitive reserve.
Takeaway
Having a good education and staying mentally active can help keep your brain healthy as you get older.
Methodology
Data from the BIOCARD study, including clinical evaluations, brain imaging, and biological sample collection over 20 years.
Participant Demographics
Cognitively unimpaired individuals, primarily middle-aged with a mean age of 57 at baseline.
Digital Object Identifier (DOI)
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