Cidofovir Activity against Poxvirus Infections
2010
Cidofovir Activity against Poxvirus Infections
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Andrei Graciela, Snoeck Robert
Primary Institution: Rega Institute for Medical Research, KU Leuven
Conclusion
Cidofovir is effective against various poxvirus infections and holds potential for therapy and prophylaxis.
Supporting Evidence
- Cidofovir has shown in vitro activity against various poxviruses including smallpox.
- It has been successfully used in humans for treating molluscum contagiosum and orf virus infections.
- Cidofovir remains a reference compound for poxvirus therapy.
- Animal studies indicate that cidofovir can significantly reduce mortality from poxvirus infections.
Takeaway
Cidofovir is a medicine that helps fight off certain viruses, especially those that cause pox diseases like smallpox and monkeypox.
Methodology
The study reviews cidofovir's antiviral activity against poxviruses based on various in vitro and in vivo studies.
Limitations
The study does not provide specific data on the long-term effects or resistance development in humans.
Digital Object Identifier (DOI)
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