Neonatal Hydrocephalus and Inflammation
Author Information
Author(s): Sival Deborah A, Felderhoff-Müser Ursula, Schmitz Thomas, Hoving Eelco W, Schaller Carlo, Heep Axel
Primary Institution: University Medical Center Groningen
Hypothesis
Pro-inflammatory cytokines could be involved in neonatal high pressure hydrocephalus (HPHC).
Conclusion
Neonatal HPHC is associated with the activation of pro-inflammatory cytokines IL-18 and IFNγ in the cerebrospinal fluid.
Supporting Evidence
- CSF IL18 concentrations were significantly higher in HPHC neonates than in controls.
- CSF IFNγ concentrations were also significantly higher in HPHC groups compared to controls.
- CSF sFasL concentrations remained within control limits.
Takeaway
Babies with a condition called high pressure hydrocephalus have higher levels of certain proteins that cause inflammation in their brain fluid, which might help explain their brain damage.
Methodology
Cerebrospinal fluid concentrations of IL18, IFNγ, and sFasL were compared between 30 HPHC neonates and 15 controls using sandwich ELISA.
Potential Biases
Potential bias in selection of control neonates.
Limitations
The study only included neonates and may not be applicable to older children or adults.
Participant Demographics
30 neonates with HPHC and 15 control neonates.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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