Tomato Lycopene Extract and Its Effects on Colitis
Author Information
Author(s): Joo Young-Eun, Karrasch Thomas, Mühlbauer Marcus, Allard Brigitte, Narula Acharan, Herfarth Hans H., Jobin Christian
Primary Institution: University of North Carolina at Chapel Hill
Hypothesis
What is the effect of tomato lycopene extract on intestinal inflammation and NF-κB signaling?
Conclusion
Tomato lycopene extract prevents LPS-induced inflammation but worsens DSS-induced colitis by increasing epithelial cell apoptosis.
Supporting Evidence
- TLE blocked LPS-induced NF-κB signaling in vitro.
- DSS-induced colitis was worsened in TLE-fed mice.
- Increased apoptosis was observed in TLE-fed, DSS-exposed mice.
Takeaway
Tomato lycopene extract can help reduce inflammation from certain triggers but can make some types of gut inflammation worse.
Methodology
Mice were fed diets with varying concentrations of tomato lycopene extract and assessed for inflammation and NF-κB signaling.
Potential Biases
Potential bias in dietary intervention effects and model selection.
Limitations
The study primarily focuses on specific mouse models and may not fully represent human responses.
Participant Demographics
NF-κBEGFP mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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