Identifying Genes Involved in Mouse Cartilage Development
Author Information
Author(s): Suwanwela Jaijam, Farber Charles R, Haung Bau-lin, Song Buer, Pan Calvin, Lyons Karen M, Lusis Aldons J
Primary Institution: UCLA, Los Angeles, CA, USA
Hypothesis
The study aims to identify cartilage gene networks that play an important role in bone development using a systems genetics approach.
Conclusion
The analysis identified several genes that may be involved in chondrocyte differentiation and bone development.
Supporting Evidence
- One module exhibited significant correlation with femur length and bone mineral density.
- Five of the 28 highly connected genes were found to play a role in chondrocyte differentiation.
- Two of the identified genes were previously known to function in chondrocyte development.
Takeaway
Researchers looked at mouse genes to understand how cartilage develops and found some important genes that help in this process.
Methodology
The study used microarray gene expression profiles from cartilage and bone phenotypic data from recombinant inbred strains of mice to identify gene networks.
Limitations
The study is broad and identifies a network of genes involved in chondrocyte development, but detailed mechanisms of action remain to be determined.
Participant Demographics
The study involved male mice from 27 different recombinant inbred strains.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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