Liver Cell Transformation in Chronic HBV Infection
2009
Liver Cell Transformation in Chronic HBV Infection
publication
Evidence: moderate
Author Information
Author(s): Benhenda Shirine, Cougot Delphine, Neuveut Christine, Marie Annick Buendia
Primary Institution: Institut Pasteur, Inserm U579
Hypothesis
What are the molecular mechanisms underlying HBV-induced tumorigenesis?
Conclusion
Chronic HBV infection is linked to liver cell transformation and hepatocellular carcinoma through various molecular mechanisms.
Supporting Evidence
- Chronic HBV infection is associated with the development of hepatocellular carcinoma.
- HBV DNA integration into host chromosomes can lead to genetic instability.
- The HBx protein plays a significant role in liver cell transformation.
Takeaway
This study looks at how the hepatitis B virus can cause liver cells to change and potentially lead to cancer.
Methodology
The study discusses various models of HBV-mediated liver cell transformation based on animal systems and functional studies in cell lines.
Digital Object Identifier (DOI)
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