L1 Cell Adhesion Molecule as a Prognostic Marker in GIST Patients
Author Information
Author(s): Zander Hilke, Rawnaq Tamina, Max Wedemeyer, Tachezy Michael, Kunkel Miriam, Wolters Gerrit, Bockhorn Maximilian, Schachner Melitta, Jakob R Izbicki, Jussuf Kaifi
Primary Institution: University Medical Center Hamburg-Eppendorf
Hypothesis
Can circulating levels of L1 cell adhesion molecule serve as a prognostic marker in gastrointestinal stromal tumor patients?
Conclusion
High soluble L1 levels predict poor prognosis in GIST patients and may be a useful tumor marker.
Supporting Evidence
- Median soluble L1 levels were significantly higher in GIST patients compared to healthy individuals.
- GIST patients with recurrence had significantly higher median soluble L1 concentrations than those without.
- Patients with high soluble L1 levels showed a significantly worse recurrence-free survival.
- The five-year recurrence-free survival rate was 52% for low soluble L1 levels and 19% for high levels.
Takeaway
This study found that patients with higher levels of a protein called L1 in their blood are more likely to have worse outcomes from their tumors.
Methodology
Soluble L1 was measured in sera of 93 GIST patients and 151 healthy controls using an enzyme-linked immunosorbent assay (ELISA).
Limitations
Some missing clinical and pathological data due to logistic difficulties in data collection.
Participant Demographics
Median age of GIST patients was 61 years, with 55% male and 45% female.
Statistical Information
P-Value
p < 0.001
Confidence Interval
95%-CI: 27; 50
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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