The Immunophilin-Like Protein XAP2 Is a Negative Regulator of Estrogen Signaling through Interaction with Estrogen Receptor α
2011
XAP2 and Its Role in Estrogen Receptor Signaling
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Cai Wen, Kramarova Tatiana V., Berg Petra, Korbonits Marta, Pongratz Ingemar
Primary Institution: Karolinska Institutet
Hypothesis
XAP2 negatively regulates estrogen receptor α (ERα) transcriptional activity.
Conclusion
XAP2 acts as a negative regulator of ERα transcriptional activity, influencing estrogen signaling.
Supporting Evidence
- XAP2 was shown to inhibit ERα-mediated transcription in MCF-7 cells.
- Knockdown of XAP2 led to increased expression of ERα target genes.
- XAP2 interacts with ERα, suggesting a direct regulatory mechanism.
Takeaway
XAP2 is like a brake for a car, stopping the estrogen receptor from going too fast and causing problems in the body.
Methodology
The study used siRNA to knock down XAP2 in MCF-7 and HeLa cells and assessed the effects on ERα-mediated transcription.
Limitations
The study primarily focused on in vitro models, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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