Intraluminal Washout in Rectal and Sigmoid Colon Cancer Surgeries
Author Information
Author(s): Shinji Furuya, Kensuke Shiraishi, Hiroki Shimizu, Koichi Takiguchi, Makoto Sudo, Hidenori Akaike, Yoshihiko Kawaguchi, Hidetake Amemiya, Tetsuo Kondo, Daisuke Ichikawa
Primary Institution: University of Yamanashi
Hypothesis
This study aimed to determine the necessity of intraluminal washout through cytological assessment to prevent implantation of exfoliated cancer cells (ECCs) in patients with rectal and sigmoid cancers.
Conclusion
In patients with sigmoid colon cancer, a 1000 mL intraluminal washout may be sufficient, while rectal cancer patients may require a 2000 mL washout.
Supporting Evidence
- 46.4% of patients initially had positive ECCs.
- After irrigation with 2000 mL, ECCs were found in only 7.3% of patients.
- Shorter distal free margins were associated with positive ECCs.
Takeaway
Doctors wanted to see if washing out the inside of the intestines during cancer surgery helps stop cancer cells from spreading. They found that washing with 1000 mL is enough for some patients, but others need 2000 mL.
Methodology
The study involved 140 patients who underwent anastomosis surgery, with intraluminal washout samples collected before and after irrigation with varying volumes of saline or distilled water.
Potential Biases
The study's findings may not be generalizable due to its single-institution design.
Limitations
The study was a single-center trial and did not randomize the irrigation solution used.
Participant Demographics
The study included 140 patients, 91 men and 49 women, with an average age of 68.9 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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