Kidney Responses to Sepsis in Pigs
Author Information
Author(s): Chvojka Jiri, Sykora Roman, Krouzecky Ales, Radej Jaroslav, Varnerova Veronika, Karvunidis Thomas, Hes Ondrej, Novak Ivan, Radermacher Peter, Matejovic Martin
Primary Institution: Charles University Medical School and Teaching Hospital Plzen
Hypothesis
Can renal haemodynamic, microcirculatory, metabolic, and histopathological responses to septic shock be assessed in a porcine model?
Conclusion
Renal venous congestion may contribute to kidney dysfunction in early septic acute kidney injury.
Supporting Evidence
- All septic pigs developed hyperdynamic shock with a 30% increase in plasma creatinine levels.
- Renal blood flow remained well-preserved despite significant renal venous pressure increases.
- Histological analysis revealed only subtle changes without signs of acute tubular necrosis.
Takeaway
When pigs get a severe infection, their kidneys can get hurt, but not in the way we thought; instead of closing off blood flow, it seems like the blood gets stuck.
Methodology
The study involved 14 pigs, with 8 receiving faecal peritonitis to induce sepsis and 6 serving as controls, measuring various renal and systemic parameters over 22 hours.
Potential Biases
Potential bias from the use of a single animal model and the specific conditions of the experiment.
Limitations
The study observed relatively mild AKI, possibly due to aggressive management, and did not measure some important renal function variables.
Participant Demographics
Median body weight of pigs was 32 kg, ranging from 27 to 35 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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