Combined directed ortho-zincation and palladium-catalyzed strategies: Synthesis of 4,n-dimethoxy-substituted benzo[b]furans
2011
Synthesis of Dimethoxy-Substituted Benzo[b]furans
publication
Evidence: moderate
Author Information
Author(s): Guilarte Verónica, Castroviejo M Pilar, Álvarez Estela, Sanz Roberto, Snieckus Victor
Primary Institution: Universidad de Burgos
Hypothesis
Can we develop a new synthetic route for regioselectively functionalized benzo[b]furans using combined directed ortho-zincation and palladium-catalyzed strategies?
Conclusion
A new synthetic route for regioselectively functionalized 4,n-dimethoxybenzo[b]furans has been successfully developed.
Supporting Evidence
- The study developed a new route to synthesize benzo[b]furan derivatives.
- The method combines directed ortho-zincation with palladium-catalyzed reactions.
- The resulting compounds have potential applications due to their interesting properties.
Takeaway
The researchers found a way to make special chemical compounds called benzo[b]furans using two different methods together, which helps create them more easily.
Methodology
The study used directed ortho-zincation followed by palladium-catalyzed reactions to synthesize the compounds.
Digital Object Identifier (DOI)
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