Early onset sebaceous carcinoma
2011
Early Onset Sebaceous Carcinoma
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Sung Dongjin, Kaltreider Sara A, Gonzalez-Fernandez Federico
Primary Institution: Department of Ophthalmology, Ross Eye Institute and State University of New York
Hypothesis
Can sebaceous carcinoma occur in young patients without a history of hereditary cancer or immunosuppression?
Conclusion
Sebaceous carcinoma can occur in young patients with no evidence of hereditary cancer risk or radiation therapy.
Supporting Evidence
- The patient had no history of retinoblastoma or hereditary cancer syndrome.
- Histopathological examination revealed a moderately well differentiated sebaceous carcinoma.
- Direct sequencing of p53 identified a G:C→A:T mutation.
Takeaway
This study shows that even young people can get a serious skin cancer called sebaceous carcinoma, even if they don't have a family history of it.
Methodology
Histopathological study including p53 DNA sequencing.
Limitations
The study is based on a single case, limiting generalizability.
Participant Demographics
A 32-year-old Caucasian woman.
Digital Object Identifier (DOI)
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