Histological Changes in Intra-Oral Skin Flaps
Author Information
Author(s): Woolgar Julia Anne, Triantafyllou Asterios
Primary Institution: University of Liverpool
Conclusion
The review highlights the diagnostic challenges and potential malignancies associated with skin flaps used in oral reconstruction.
Supporting Evidence
- Chronic candidiasis was evident in 75% of punch biopsies in a study on the adaptive properties of the transferred skin.
- 5% of patients developed a new primary tumor at the skin flap/mucosal junction.
- 25% of skin flap lesions diagnosed as chronic hyperplastic candidiasis showed features of squamous epithelial dysplasia.
Takeaway
This study looks at how skin flaps used in mouth surgeries can change and sometimes show signs of disease, making it important for doctors to check them carefully.
Methodology
The review is based on long-term experience with routine diagnostic material and focuses on the morphology and pathogenesis of lesions.
Potential Biases
The findings may be influenced by the clinical expertise of the surgical oncologists and the selective nature of biopsies.
Limitations
The study is based on a relatively small sample size and may be biased towards suspicious lesions due to selective biopsy.
Participant Demographics
Patients with squamous cell carcinoma of the mouth and oropharynx.
Digital Object Identifier (DOI)
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