The Role of Interferon Antagonist Proteins in Arboviruses
Author Information
Author(s): Hollidge Bradley S., Weiss Susan R., Soldan Samantha S.
Primary Institution: University of Pennsylvania School of Medicine
Hypothesis
The review explores how non-structural proteins of arboviruses act as interferon antagonists and their role in virus emergence.
Conclusion
Arboviruses utilize non-structural proteins to counteract the host's interferon response, which is crucial for their emergence and pathogenicity.
Supporting Evidence
- Arboviruses represent over 30% of all emerging infectious diseases identified in the past decade.
- Non-structural proteins of arboviruses act as interferon antagonists, enhancing their ability to establish infections.
- Understanding these mechanisms may lead to the development of vaccines and antiviral therapies.
Takeaway
Some viruses have special proteins that help them hide from the body's defenses, making it easier for them to spread and cause sickness.
Methodology
The review summarizes various mechanisms by which arboviruses evade the host immune response, particularly focusing on non-structural proteins.
Limitations
The review does not provide experimental data but rather synthesizes existing literature on the topic.
Digital Object Identifier (DOI)
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