Silver Nanoparticles Enhance HIV-1 Neutralization by Antibodies
Author Information
Author(s): Lara Humberto H, Ixtepan-Turrent Liliana, Garza Treviño Elsa N, Singh Dinesh K
Primary Institution: Winston-Salem State University
Hypothesis
The combination of silver nanoparticles and neutralizing antibodies will increase the inhibition of cell-associated HIV-1 infection.
Conclusion
The addition of silver nanoparticles to neutralizing antibodies significantly increased their potency in preventing cell-associated HIV-1 transmission.
Supporting Evidence
- Silver nanoparticles alone inhibited cell-associated HIV-1 infection by 50%.
- Neutralizing antibodies showed little effect on cell-associated HIV-1 infection without silver nanoparticles.
- Combining silver nanoparticles with neutralizing antibodies resulted in 60-71% inhibition of cell-associated HIV-1 infection.
Takeaway
Using tiny silver particles with special antibodies can help stop the spread of HIV better than using the antibodies alone.
Methodology
The study tested the effects of silver nanoparticles combined with four different neutralizing antibodies on HIV-1 infection in vitro.
Limitations
Further exploration is required to standardize the potentiation of neutralizing antibodies by silver nanoparticles and evaluate their in vivo toxicity.
Statistical Information
P-Value
p<0.002
Statistical Significance
p<0.002
Digital Object Identifier (DOI)
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