Cortisol and Inflammatory Insulin Resistance
Author Information
Author(s): Michael Lehrke, Uli C Broedl, Ingeborg M Biller-Friedmann, Michael Vogeser, Volkmar Henschel, Kirsten Nassau, Burkhard Göke, Erich Kilger, Klaus G Parhofer
Primary Institution: University of Munich
Hypothesis
What are the roles of different serum factors in predicting insulin resistance during acute inflammation?
Conclusion
Cortisol is the best predictor of inflammatory insulin resistance, followed by IL6, leptin, and adiponectin.
Supporting Evidence
- Cortisol levels increased during surgery and were the strongest predictor of insulin resistance.
- IL6, leptin, and adiponectin also predicted insulin resistance but to a lesser extent.
- TNFα and resistin were found to have minor relevance in predicting insulin resistance.
Takeaway
When people have surgery, their bodies can become resistant to insulin, which helps control blood sugar. The study found that cortisol is the best indicator of this insulin resistance.
Methodology
Insulin resistance was measured in 37 non-diabetic patients undergoing cardiac surgery by assessing insulin requirements and serum levels of various factors over 48 hours.
Potential Biases
The study cannot rule out the influence of other mediators of insulin resistance.
Limitations
The study used an insulin glycaemic index, which is less precise than the gold standard insulin clamp method, and had a relatively small sample size.
Participant Demographics
{"age":"69 (60 to 74)","sex_distribution":{"male":23,"female":14},"body_mass_index":"27.1 (23.1 to 29.9)"}
Statistical Information
P-Value
<0.0001
Confidence Interval
0.43 to 0.71
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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