Role of DHX32 in Colorectal Cancer
Author Information
Author(s): Huang Chunling, Liang Xianming, Huang Ruxin, Zhang Zhongying
Primary Institution: Xiamen Center for Clinical Laboratory, Xiamen Zhongshan Hospital, Xiamen University
Hypothesis
This study aimed to find novel biomarkers for colorectal cancer.
Conclusion
DHX32 may play an important role in the development of colorectal cancer and could serve as a novel biomarker for colorectal cancer after additional investigation.
Supporting Evidence
- DHX32 was significantly up-regulated in colorectal cancer compared to adjacent normal tissues.
- The positive rate of DHX32 gene expression was significantly higher in colorectal tumors (76.5%) than in adjacent normal tissues (26.4%).
- DHX32 gene expression was associated with cancer location, lymph gland metastasis, cancer nodal status, differentiation grade, and Dukes' stage.
Takeaway
Researchers found a new gene called DHX32 that is more active in colorectal cancer than in normal tissue, which might help doctors understand and treat the disease better.
Methodology
Fluorescent mRNA differential display PCR (DD-PCR) was used to screen genes in colorectal cancer tissues, confirmed by real-time PCR.
Participant Demographics
{"age":{"under_59":25,"over_59":23},"gender":{"male":22,"female":26},"tumor_location":{"colon":10,"rectum":38},"lymph_metastases":{"positive":27,"negative":21},"tumor_nodal":{"positive":20,"negative":28},"tumor_differentiation":{"poor":9,"median_well":39},"dukes_stage":{"A+B":21,"C+D":27}}
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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