Link Between Plasma A-FABP Levels and Coronary Artery Disease in Men
Author Information
Author(s): Doi Masayuki, Miyoshi Toru, Hirohata Satoshi, Nakamura Kazufumi, Usui Shinichi, Takeda Ko, Iwamoto Mutsumi, Kusachi Shozo, Kusano Kengo, Ito Hiroshi
Primary Institution: Kagawa Prefectural Central Hospital, Kagawa, Japan
Hypothesis
Is increased plasma A-FABP level independently associated with the presence of coronary artery disease (CAD)?
Conclusion
Higher plasma A-FABP levels in non-elderly men are significantly associated with the presence of CAD, independent of other risk factors.
Supporting Evidence
- Plasma A-FABP levels in CAD patients were significantly higher than in control subjects.
- An increased plasma A-FABP level was independently associated with the presence of CAD.
- This association remained significant in subjects aged under 65 years.
Takeaway
This study found that men with higher levels of a specific protein in their blood are more likely to have heart disease.
Methodology
The study involved 211 male CAD patients and 211 age-matched controls, measuring plasma A-FABP levels using enzyme-linked immunosorbent assays.
Potential Biases
Potential selection bias due to the study's focus on hospitalized patients.
Limitations
The study focused only on male patients, which may limit the generalizability of the findings to females.
Participant Demographics
All participants were male, with a mean age of 66 years.
Statistical Information
P-Value
0.01
Confidence Interval
1.14 to 2.70
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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