Meta-Analysis of HOXA1 and HOXB1 Variants and Autism Risk
Author Information
Author(s): Song Ran-Ran, Zou Li, Zhong Rong, Zheng Xia-Wen, Zhu Bei-Bei, Chen Wei, Liu Li, Miao Xiao-Ping
Primary Institution: Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Hypothesis
The study investigates the association between HOXA1 A218G and HOXB1 nINS/INS variants and the risk of Autism Spectrum Disorders (ASD).
Conclusion
The meta-analysis suggests that the HOXA1 A218G and HOXB1 nINS/INS variants may not contribute significantly to ASD risk.
Supporting Evidence
- The study included 11 reports in the meta-analysis.
- Overall, no significant association was found between the variants and ASD risk.
- The cumulative analysis showed a tendency toward null-significant association over time.
Takeaway
The study looked at two specific gene changes to see if they are linked to autism, but found that they probably aren't.
Methodology
The study conducted a meta-analysis integrating case-control and transmission/disequilibrium test studies to assess the association of HOXA1 and HOXB1 variants with ASD.
Potential Biases
Potential biases may arise from mixed population samples and varying age ranges of controls.
Limitations
The study faced limitations due to the heterogeneous nature of included studies and the inability to analyze gene-gene interactions.
Participant Demographics
The study included participants from various ethnic backgrounds, including White, Black, Yellow, and Indian populations.
Statistical Information
P-Value
P=0.843 for HOXA1 A218G and P=0.118 for HOXB1 nINS/INS.
Confidence Interval
95% CI for HOXA1 A218G: 0.76-1.25; 95% CI for HOXB1 nINS/INS: 0.97-1.33.
Digital Object Identifier (DOI)
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