Cost-effectiveness of Rotavirus Vaccination in the Netherlands
Author Information
Author(s): Mark H Rozenbaum, Marie-Josee J Mangen, Carlo Giaquinto, Jan C Wilschut, Eelko Hak, Maarten J Postma
Primary Institution: University of Groningen
Hypothesis
What factors impact the cost-effectiveness of rotavirus vaccination in the Netherlands?
Conclusion
Including rotavirus vaccination in the Dutch National Immunization Program could be cost-effective depending on vaccine costs and the impact of rotavirus on children's quality of life.
Supporting Evidence
- Rotavirus vaccination could avert 34,214 cases of gastroenteritis in children under 5.
- Vaccination could prevent approximately €6.3 million in direct costs and €1.3 million in indirect costs.
- The cost-effectiveness ratio varies significantly based on vaccine costs and QALY estimates.
Takeaway
Vaccinating kids against rotavirus can save a lot of hospital visits and money, but it needs to be affordable to be worth it.
Methodology
A cohort model was developed to compare the current situation without vaccination to mass universal RV vaccination over a 5-year period.
Potential Biases
Potential biases in the estimates of QALY losses and the impact of herd immunity were noted.
Limitations
The analysis did not include indirect protective effects for unvaccinated individuals and did not account for QALY losses in caregivers.
Participant Demographics
The study focused on a hypothetical cohort of 180,000 newborns in the Netherlands.
Statistical Information
Confidence Interval
95% CI 63.2%-78.9%
Digital Object Identifier (DOI)
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