MIG is a better measure than IFN-γ for T-cell responses to malaria vaccines
Author Information
Author(s): Berthoud Tamara K., Dunachie Susanna J., Todryk Stephen, Hill Adrian V.S., Fletcher Helen A.
Primary Institution: University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine
Hypothesis
Can MIG (CXCL9) provide a more sensitive measure of vaccine-induced T-cell responses compared to IFN-γ?
Conclusion
MIG detection is more sensitive than IFN-γ detection for measuring T-cell responses in malaria vaccine trials.
Supporting Evidence
- Detection of MIG was shown to be more sensitive than IFN-γ in measuring immune responses.
- MIG secretion showed little inter-individual variability.
- Five positive MIG responses were detected at V3+7 compared to two for IFN-γ.
Takeaway
This study shows that measuring a substance called MIG can help scientists see how well a malaria vaccine works better than measuring another substance called IFN-γ.
Methodology
The study involved a phase I vaccine trial where volunteers were vaccinated and their immune responses were measured using MIG and IFN-γ detection methods.
Limitations
The study's findings may not be generalizable beyond the specific vaccine regimen tested.
Participant Demographics
Malaria-naive, male or female Caucasians aged 18–65 years.
Statistical Information
P-Value
0.013
Statistical Significance
p=0.013
Digital Object Identifier (DOI)
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