Genetic Differences Between Salmonella paratyphi C and Other Typhoid Agents
Author Information
Author(s): Liu Wei-Qiao, Feng Ye, Wang Yan, Zou Qing-Hua, Chen Fang, Guo Ji-Tao, Peng Yi-Hong, Jin Yan, Li Yong-Guo, Hu Song-Nian, Johnston Randal N., Liu Gui-Rong, Liu Shu-Lin
Primary Institution: Genomics Research Center, Harbin Medical University, Harbin, China
Hypothesis
Are the typhoid agents like Salmonella paratyphi C and Salmonella typhi products of divergent evolution or convergent evolution?
Conclusion
Salmonella paratyphi C has diverged from a common ancestor with Salmonella choleraesuis, supporting the convergent evolution model of the typhoid agents.
Supporting Evidence
- Salmonella paratyphi C shares more genes with Salmonella choleraesuis than with Salmonella typhi.
- The study found distinct sets of pseudogenes between Salmonella paratyphi C and Salmonella choleraesuis.
- Phylogenetic analysis indicates a recent divergence between Salmonella paratyphi C and Salmonella choleraesuis.
Takeaway
This study shows that Salmonella paratyphi C is not closely related to other typhoid bacteria, meaning they didn't come from the same ancestor but evolved similar traits separately.
Methodology
The genome of Salmonella paratyphi C was sequenced and compared with other Salmonella strains to analyze genetic similarities and differences.
Limitations
The study may not have identified all genes contributing to typhoid pathogenicity due to the genetic similarities among the strains compared.
Digital Object Identifier (DOI)
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