Age Distribution of Cases of 2009 (H1N1) Pandemic Influenza in Comparison with Seasonal Influenza
2011

Age Distribution of 2009 H1N1 Pandemic Influenza Compared to Seasonal Influenza

Sample size: 45032 publication 10 minutes Evidence: high

Author Information

Author(s): Karageorgopoulos Drosos E., Vouloumanou Evridiki K., Korbila Ioanna P., Kapaskelis Anastasios, Falagas Matthew E.

Primary Institution: Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece

Hypothesis

Does the age distribution of cases differ between the 2009 H1N1 pandemic influenza and seasonal influenza?

Conclusion

The 2009 H1N1 pandemic influenza primarily affected school-aged children, adolescents, and younger adults compared to seasonal influenza.

Supporting Evidence

  • The greatest increase in influenza cases during the pandemic was seen for school-aged children and younger adults.
  • Pediatric deaths were less likely in younger age groups compared to older children.
  • Influenza-like illness visits increased significantly among younger populations during the pandemic.

Takeaway

During the 2009 H1N1 pandemic, more young people got sick compared to older people, unlike what usually happens with seasonal flu.

Methodology

Data was collected from various health organizations worldwide on age distribution of influenza cases during the pandemic and recent seasonal periods.

Potential Biases

Potential biases include differences in health-seeking behavior and diagnostic methods between pandemic and seasonal periods.

Limitations

The study's data is limited to developed countries and may not represent global trends.

Participant Demographics

Data included various age groups, with a focus on children, adolescents, and young adults.

Statistical Information

P-Value

<0.001

Confidence Interval

95% CI: 1.89 (1.75–2.05), 5.33 (4.90–5.79), 7.19 (6.67–7.75), etc.

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1371/journal.pone.0021690

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